The role of fructose 2,6 bisphosphate in the regulation of metabolism is as ATP's inhibition is removed, glycolysis may continue giving to fructose 2,6-bisphosphate. Fructose 2,6 bisphosphate is synthesized in the glycolysis process.
Enzymes that synthesize fructose 2,6 bisphosphate are regulated in order to control the amount of fructose-2,6-bisphosphate, an enzyme with two distinct functions must be present. As the glycolysis rate-limiting enzyme, fructose-2,6-bisphosphate acts as a strong allosteric activator. As a result, inhibiting glycolysis causes the pentose phosphate pathway shunt to become the new site of cellular glucose metabolism. As the glycolysis rate-limiting enzyme, fructose-2,6-bisphosphate acts as a strong allosteric activator.
Pase-2 controls the synthesis and breakdown of Fru-2,6-P2, thereby regulating the amount of the compound in cells. The main regulators influence the enzyme through phosphorylation and dephosphorylation processes.
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