Yes, knowledge can be independent of culture natural science.
What do you mean by knowledge?
Knowledge can be characterised as factual information or as useful abilities, and it can also relate to acquaintance with things or circumstances. The term "knowledge of facts," also known as "propositional knowledge," refers to a real belief that may be distinguished from an opinion or educated guess by the use of evidence. Although most philosophers agree that propositional knowledge is a type of genuine belief, many philosophical debates centre on the issue of justification, including whether it is even necessary, how to define it, and whether anything else besides it is required. These debates grew more heated as a result of Edmund Gettier's series of thought experiments, which led to the emergence of numerous different definitions.
Unaffected by culture, knowledge exists, of course. Fundamental mathematics and the basic physics of the cosmos are unaffected by culture (despite what some have been trying to claim recently).
So, yes knowledge can be independent of culture natural science.
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