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ion-ion, is the dominant intermolecular force that determines the solubility of the amine hydrochloride salt of ethyl 4-aminobenzoate in water.
What is hydrochloride ?
It is standard practice to transform amines into their hydrochlorides in order to increase their water solubility, which might be advantageous for compounds used in pharmaceuticals. More than 200 hydrochlorides are listed as active components in pharmaceuticals in the European Pharmacopoeia. In comparison to free bases, these hydrochlorides might dissolve more easily in the digestive system and be absorbed into the bloodstream faster. Furthermore, many amine hydrochlorides have a longer shelf life than their corresponding free bases.
Amine hydrochlorides are latent forms of a free base, which is more reactive. In this sense, protection is granted by the production of an amine hydrochloride. The hydrochlorides of the amino acids serve as an example of this phenomenon. Shelf-stable glycine methyl ester hydrochloride is easily transformed into reactive glycine methyl ester, a substance.
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