At age 65, lowering systolic or diastolic blood pressure by 10 or 5 mm Hg, respectively, reduces the risk of stroke by around 35% and the risk of ischemic heart disease (IHD) events by about 25%.
How dosage of medication reduce blood pressure?
- Blood pressure-lowering medications are frequently used to lower blood pressure, however it is unknown which medications are best to use, if drug combinations should be regularly used, and whether lower doses than those now prescribed are desirable.
- The effects of dose modification or combination therapy have not been investigated in large studies or comprehensive reviews.
- Even though side effects were substantially less frequent, the reduction in blood pressure was only 20% less at half the usual dose than at the standard dose.
- Drug combinations increased efficacy, although bad effects were less common than increased it.
- As a result, combinations of two to three medications taken at low doses are preferred to one or two drugs used at a regular dosage.
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