If mutant HMGN2 proteins were unable to bind their substrate and then erroneously mobilized to nucleoli, these proteins would be found in the sites of Ribosome production.
- In this case, mutant HMGN2 proteins deploy inadvertently to nucleoli. The nucleolus, a bulky, globular structure inside the nucleus of eukaryotic cells, houses ribosomal DNA.
- Here, the pre-ribosomal RNA (rRNA) gene is solely translated into a single template that is then processed to produce mature rRNA by RNA polymerase I.
- As a result, the nucleolus is the only location where RNA polymerase I can work.
- Additionally, ribosomal subunit maturation and assembly take place in the nucleolus.
- The cytoplasm produces ribosomal proteins from mRNA, which are then carried into the nucleolus where they interact with newly produced rRNA to generate the precursors to the 40S and 60S subunits.
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