In a case-control study, a researcher found no association between exposure to A and disease B. Later she found out that there was a misclassification when measuring exposure to A, in both cases and controls. What is a potential explanation for the results (no association) of this case-control study

Respuesta :

Nondifferential misclassification.

The misclassification's impact on both cases and controls suggests that it was nondifferential, which weakens the link between A and B.

What is non-differential misclassification?

Non-differential classification error occurs when data is wrong but consistent across groups. When the disease is unconnected to other variables (including exposure) or when exposure is unrelated to other variables (including disease), it occurs. Non-differential misclassification bias typically follows a predictable pattern (it tends to the null value), although this isn't always the case. There may be a bias away from the null when there are three or more exposure groups (levels).

  • Non-differential misclassification in case-control studies can occur when the exposure status is erroneous for both controls and cases.
  • It occurs in cohort studies when the exposure status for those with the disease and those without it is misclassified.

Learn more about non-differential misclassification here:

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