Both genetic and nongenetic factors cause the congenital skeletal abnormality known as clubfoot, which occurs with a worldwide incidence of about 1 in 1000 births. gurnett et al. identified a family in which clubfoot occurred as an autosomal dominant trait due to a mutation in the pitxi gene. dna testing revealed that 11 people in the family carried the pitxi mutation, but only 8 of these people had clubfoot. calculate the penetrance of the pitxi mutation in this family.

Respuesta :

The penetrance of a gene mutation is calculated by dividing the number of people expressing the phenotypic trait by the total number of people that carry the mutant gene, expressed on percentage.

Number of people with club foot in the family = 8
Number of people with mutant PIXTI gene in the family = 11

Penetrance of PIXTI mutation in the family = (8/11) * 100%
= 72.7% (or Approximately 73%)