Step 1
chondrocytes in the center of hyaline cartilage enlarge & form struts which begin to calcify. Then the enlarged chondrocytes die, leaving cavities in the cartilage
Step 2
Blood vessels grow around the edges of cartilage; cells in the perichondrium change to osteoblasts, producing a layer of superficial bone around the shaft which will continue to grow & become compact bone (appositional growth)
Step 3
Blood vessels enter the cartilage, bringing osteoblasts, spongy bone develops at the primary ossification center
Step 4
Remodeling creates a marrow cavity, bone replaces cartilage at the metaphyses
Step 5
Capillaries & osteoblasts enter the epiphyses, creating secondary ossification centers
Step 6
Epiphyses fill with spongy bone, cartilage remaining within the joint cavity is the articulation cartilage (Hyaline cartilage only in this phase)
