Which of these factors contributed to the development of Roman civilization? Select all that apply.

Rome’s geography protected the city from invaders.
Rome’s central location made it a center for trade throughout the Mediterranean.
Rome’s lack of natural resources encouraged expansion.
Rome’s distance from Greece protected its culture from Greek influence.

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Rome's geography protected the city from invaders. 
Rome's central location made it a center for trade throughout the
Mediterranean.

The factors from the list that were of great importance when it came to the development of Roman civilization was Rome's geography was so that it protected the city from foreign invaders, and Rome was in a great location that was very central, it made it easy for Rome to trade all throughout the mediterranean.
1) Rome’s geography protected the city from invaders.2) Rome’s central location made it a center for trade throughout the Mediterranean.

Summarizing the first answer so there can be less reading for some people