The choices of the question are:
A. intoxication ratio
B. neuron ratio
C. neurotransmitter ratio
D. psychoactivity ratio
E. safety or therapeutic margin
The answer is E. safety or therapeutic margin. It gives the range whether a drug dose can give its efficacy or toxicity. A high TI or therapeutic Index that is needed by a drug. To ensure that the drug can give a therapeutical effect it undergoes therapeutic drug monitoring.
