The organelle responsible for the synthesis of fatty acids and steroid hormones is called smooth endoplasmic Reticulum. The smooth endoplasmic reticulum, or smooth ER, is an organelle found in both animal cells and plant cells. It's main function is to produce lipids (fatty acids) and steroid hormones.Smooth ER also makes or distributes products according to its location. In muscle cells, it releases calcium ions because they are required for muscle contraction. In cells of the endocrine system, which is responsible for regulating hormones, smooth ER makes steroid hormones.