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A man is heterozygous for sickle cell anemia and homozygous dominant for familial hypercholesterolemia. Knowing that these genes are located on different chromosomes and using the information below, predict his possible sperm. Sickle Cell Anemia A=Normal hemoglobin a=Abnormal hemoglobin (Sickle Cell) B=Familial Hypercholesterolemia (abnormal LDL protein receptor) b=Normal LDL protein receptor)

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JcAlmighty
The answer is AB and aB

A man is heterozygous for sickle cell anemia: Aa
A man is homozygous dominant for familial hypercholesterolemia: BB

So, his genotype is AaBB. He will give only one allele of two for each gene.
He can have 2 different combinations in sperm cells:
- AB
- aB

Because of the law of independent assortment, alleles on different chromosomes sort independently of one another during the formation of sex cells. Because of the law of segregation, alleles of the same gene do not end up in the same sex cell during meiosis.

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