start by looking at simplifying the smaller problems
anything to the power zero is 1[tex] 6^0 = 1[/tex]
next apply the power of a power rule... multiply the powers
[tex](2^8\times 3^{-5} \times 1 )^{-2} = 2^{8\times -2}\times 3^{-5 \times -2}[/tex]
which becomes
[tex]2^{-16}\times 3^{10}[/tex]