Enhancer regions serve as locations or binding sequences for particular transcription factors. A protein transcription factor binds to its enhancer sequence and activates the gene.
There are areas in several eukaryotic genes that aid in enhancing or increasing transcription. These areas, which are referred to as enhancers, are not always adjacent to the genes they enhance. They may be thousands of nucleotides apart, within the gene's coding region, downstream of the gene, or upstream of the gene. The shape of a protein changes when a protein transcription factor binds to its enhancer sequence, enabling it to interact with proteins at the promoter region. The DNA must bend to allow the proteins at the two locations to interact, while the enhancer region may be far from the promoter. The enhancer and promoter regions are brought together by the DNA being bent by DNA bending proteins.
Hence, enhancer upregulate gene expression on binding to promoter.
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