Proteases, enzymes that break down proteins, did not eliminate the transforming principle, according to Avery and McCarty.
Studying the pneumonia-causing bacteria Streptococcus pneumoniae allowed Oswald Avery, Colin MacLeod, and Maclyn McCarty to demonstrate how DNA, not proteins, can change a cell's characteristics and shed light on the chemical makeup of genes. Over the following 15 years, Avery and members of his group conducted intermittent studies on metamorphosis. They started working together in earnest to clarify the "transforming principle" and comprehend its chemical makeup in the early 1940s.
Neither did the lipid-digesting enzymes known as lipases. They discovered that the transforming substance had a lot of nucleic acids, but ribonuclease, which breaks down RNA, did not render it inactive. The transforming principle has a large molecular weight, they discovered as well. DNA had been extracted.
Hence, DNA is transforming principle that lost working on digestion .
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