Assuming no gene linkage, in a dihybrid cross of AABB x aabb with AaBb F1 heterozygotes, the ratio of the F1 gametes (AB, aB, Ab, ab) that will give rise to the F2 offspring is 1:1:1:1.
Gene linkage is the proclivity of genes or segments of DNA closely located somewhere along chromosomes to segregate together during meiosis and thus be inherited together.
Gene linkage evaluation is an effective method for determining the chromosomal position of disease genes. It is based on the discovery that genes that are physically close to one another on a chromosome stay connected during meiosis.
Genes that are close enough together on a chromosome will often seem to "stick together," and the variants (alleles) of those genes that are close together on a chromosome will more often than not be inherited as a pair. This is known as genetic linkage or gene linkage.
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