A germline mutation can cause cancer susceptibility to run in families.
When your cells split and duplicate, countless genetic changes are conceivably possible. There are two different kinds of genetic mutations:
A genetic alteration occurs in a reproductive cell (egg or sperm) and is absorbed into the DNA of every cell in the offspring’s body. A variation (or mutation) present in the germline that can be passed from parent to child is said to be inherited. Also known as a germline variation.
Somatic mutations are modifications to a person’s DNA that take place in any cell that isn’t a germ cell after conception (egg or sperm cell). Somatic mutations, which are not hereditary and occur sporadically or randomly, are unrelated to a person’s family history and are not passed down from parents to children. They also cannot be passed on to subsequent generations.
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