Prophase is the longest and initial stage of mitosis. The nuclear envelope, the membrane that encloses the nucleus, ruptures as chromatin condenses into chromosomes during prophase.
Prophase: The cell's nuclear envelope, which houses the 92 sister chromatids, starts to degrade during prophase. Animal cells are the only cells that include centrioles, which split apart and migrate to opposing ends of the cell.
The two pairs of centrioles travel to their opposing poles during prophase, and microtubules start to develop from the duplicate centrosomes. This is when the spindle also starts to form.
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