Respuesta :
Methyl-directed mismatch repair (MMR) of DNA is the primary mechanism for correcting mismatched base pairs caused by DNA polymerase.
What is Methyl-directed mismatch repair?
In E. coli, the methyl-directed mismatch repair (MMR) system is initiated after replication, and one of its main functions is to repair base mismatches and small insertion-deletions caused by misincorporation and strand slippage during DNA replication. It is to remove lost loops. The MMR methyl group indicates the parent strand of DNA.
Mismatches are often due to base tautomerism during DNA replication. It recognizes deformation due to mismatches, distinguishes template strands from non-template strands, cuts out erroneously incorporated bases, and replaces them with correct bases to repair damage.
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