Lipid-derived (soluble) hormones can enter the cell via passing through the plasma membrane, binding to DNA, and controlling gene transcription as well as altering the functions of the cell by triggering the creation of certain proteins.
These hormones must pass the cell membrane in order to enter the cell. The hormone-receptor complex attaches to certain DNA sequences and then travels into the nucleus where it functions as a transcription factor to either increase or decrease the production of particular genes.
Since cell membranes are composed of a lipid bilayer, lipid-soluble hormones can diffuse directly across both the membranes of the target cell and the endocrine cell where they are produced.
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