The majority of DNA damage is repaired by removing the harmed bases and then resynthesising the excised area.
Briefing:
However, some DNA lesions can be directly reversed, which may be a more effective method of handling some types of DNA damage that happen frequently.
The three major types of polymerases found in prokaryotes are known as DNA pol I, DNA pol II, and DNA pol III. DNA pol III is now understood to be the enzyme needed for DNA synthesis, whereas DNA pol I and DNA pol II are mainly needed for repair.
In order for the cells to repair the DNA damage, at least five major DNA repair pathways—base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), homologous recombination (HR), and non-homologous end joining (NHEJ)—are active at various times during the cell cycle.
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