The conclusion that we can draw about the chemicals released in the inflammatory response is that HMG1 acts as a mediator of acute lung inflammation might leads to lung cancer, such as mesothelioma. The presence of HMG1 causes cells to release certain chemicals that promote tumor growth.
Asbestos is a crystalline category of naturally occurring silicate fibers. These fibers are only visible under a microscope. Asbestos harms lung tissue cells by inducing programmed cell death. When cells die in this way, they produce HMG1 (high mobility group proteins 1) that promotes an inflammatory reaction in other cells. Cells release substances that stimulate tumor development during this inflammatory reaction. In humans, asbestos fibers cause mesothelioma, a type of cancer. Mesothelioma is typically lethal. These asbestos-related diseases do not show themselves immediately but may appear 20 to 50 years after exposure.
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