Respuesta :
Acetyl-CoA builds up in the liver, where it mixes with other substances to create ketone bodies through a process called ketogenesis. Insufficient insulin production by the pancreas characterizes Type I diabetes mellitus.
Within 30 minutes after eating a meal containing carbohydrates, blood sugar levels increase. Acetyl CoA is redirected to produce ketone bodies if too much acetyl CoA is produced during the oxidation of fatty acids and the Krebs cycle is overburdened and unable to manage it. If the body's glucose levels are too low, these ketone bodies can act as a fuel source. A molecule known as acetyl-CoA (acetyl coenzyme A) is involved in a variety of metabolic processes in the metabolism of proteins, carbohydrates, and lipids.
High levels of nucleocytosolic acetyl-CoA are indicative of a "growth" or "fed" state and encourage its use for histone acetylation and lipid synthesis.
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