b. It inhibits the cell cycle
p53 gene product inhibits the cell cycle for preventing replication of damaged DNA. Main function of p53 gene product are: growth arrest by inhibiting cell cycle, DNA repair and apoptosis (cell death). That means p53 gene product arrest the growth of cell cycle when there is any damaged DNA.
A regulatory protein called p53 that is often mutated in human malignancies is also known as tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53). The p53 proteins, which were once believed to be a single protein and are sometimes referred to as such, are essential in vertebrates because they inhibit the development of cancer. As a result of its function in preserving stability by guarding against genome mutation, p53 has been referred to as "the guardian of the genome." As a result, the gene TP53[note 1] is categorized as a tumor suppressor.
In 1979, the term "p53" was coined to describe the apparent molecular mass; SDS-PAGE examination reveals that the protein is 53 kilodalton (kDa) in size.
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