A gene fusion where the regulatory region of one gene is fused to the open reading frame of another gene whose protein product is easy to detect reporter gene.
A gene created by combining sections of two different genes. Fusion genes and the fusion proteins that result from them can be created in the laboratory or naturally in the body when a piece of DNA from one chromosome moves to another. The most common type of mutation is gene fusions or translocations caused by chromosomal rearrangements. They result in chimeric transcripts or gene deregulation due to the juxtaposition of novel promoter or enhancer regions.
A reporter gene is an exogenous coding region that is linked to a promoter sequence or element in an expression vector and introduced into cells to provide a means of measuring promoter activity.
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