The blank AT/GC rule states that blank complementarity between DNA strands is necessary for DNA replication.
Chargaff's Rule states that during the replication process, all replication must match complementary purines, pyrimidines, or nitrogenous bases. DNA always couples adenine and thymine together, but cytosine always couples with guanine.
According to the base pairing rule, guanine always joins with cytosine, whereas adenine always unites with thymine. They keep the two strands of DNA connected, but they are too weak to undergo replication.
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