The mutation in the 3' end of a mammalian gene that changes the sequence AAUAAA (poly-A tail) will affect the stability of the m-RNA molecule.
Poly-A tail in mammalian gene is composed of the sequence AAUAAA. It us very essential for providing the m-RNA molecule its stability. Its presence also prevents the degradation of the RNA. Another function of poly-A tail is to guide the transport of newly synthesized RNA molecule from the nucleus to the cytoplasm for translation.
m-RNA is the messenger RNA. It is the RNA that actually encodes the genetic information from the DNA and transfers it to the protein. m-RNA when newly synthesized is called the hn-RNA and is formed into complete m-RNA only after undergoing certain processing.
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