The European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) released diagnostic criteria for celiac disease (CD) in 1990. Since then, tissue transglutaminase, the CD autoantigen, has been discovered, and CD has evolved from being thought of as a rare enteropathy to a common multiorgan illness that is highly dependent on the HLA-DQ2 and HLA-DQ8 haplotypes. CD-specific antibody tests have also improved. The new recommendations aimed to improve diagnostic accuracy and lessen the strain on patients and their families. It is important to evaluate these recommendations' efficacy in clinical settings prospectively. A 17-person expert panel used the Delphi approach to define CD and create new diagnostic standards.
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