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after several decades with aluminum salts (alum) as the only approved vaccine adjuvant, there is now a growing list of adjuvants and multicomponent nanoparticle-based vaccine formulations emerging which represent promising approaches for improving the safety and efficacy profiles of protein-based vaccines

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There have been more vaccines recently that contain thermostable adjuvants, and significant advancements have been achieved in improving the stability of the main classes of adjuvants.

What are the safety and efficacy profiles of protein based vaccines?

A protein's subunit The "spike protein" is a protein found in COVID-19 vaccinations that is made up of bits of the virus that causes COVID-19. In addition to the protein component, COVID-19 vaccines also include an adjuvant, which aids the immune system's eventual response to the virus.

Real-time PCR-confirmed Covid-19 symptoms that appeared at least 7 days after the third dose served as the primary efficacy end goal. Severe to critical Covid-19, including mortality linked to Covid-19, occurring at least 7 days after the third dose were important secondary effectiveness end goals.

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