Respuesta :
1) He expanded his study area beyond Kenya to the rest of East Africa to see if malaria and sickle disease were connected.
2) He evaluated blood samples for malaria parasites and the presence of sickle cells.
These two answers are that sickle cell disease was connected to malaria.
What connection did Dr. Allison observe between sickle cell and malaria?
- In 1949, British geneticist Anthony Allison found that the frequency of sickle cell carriers in tropical Africa was higher in regions where malaria raged all year long.
- Blood tests from children hospitalized with malaria found that nearly all were homozygous for the wild type of sickle cell allele.
- When heterozygotes have an advantage over people who have two copies of the wild-type allele, a disease can continue to be prevalent.
- Balanced polymorphism is at play when carriers have advantages that allow a harmful allele to survive in a population.
- Heterozygosity for an inherited disease that offers protection from an infectious disease is frequently associated with this type of polymorphism. The examples are interesting.
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