Ligand-gated ion channel is this process describing four transmembrane regions changes conformation as Gaba binds.
In addition to being a ligand-gated ion channel, the [tex]GABA_A[/tex] receptor ( [tex]GABA_A[/tex] R) is an ionotropic receptor. Aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system, is its endogenous ligand.
The postsynaptic cell's [tex]GABA_A[/tex] receptor opens up to chloride ions (Cl) and, to a lesser extent, bicarbonate ions (HCO3); this selective permeability is known as the [tex]GABA_A[/tex] receptor.
Depending on the membrane potential and the differential in ionic concentration, this may cause ionic fluxes across the pore. When the receptor is active, Cl will flow into the cell if the membrane potential is greater than the equilibrium potential, sometimes referred to as the reverse potential, for chloride ions.
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