A drastic conformational change in proteins in response to conditions such as extreme heat or ph will lead to loss of a protein's function. this drastic change in three-dimensional shape is called:_________

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12-09-2022
Social Studies

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A drastic conformational change in proteins in response to conditions such as extreme heat or ph will lead to loss of a protein's function. this drastic change in three-dimensional shape is called:_________

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Tutorconsortium250 Tutorconsortium250 · Answer 1 · 2022-09-17T19:18:08+02:00

A drastic conformational change in proteins in response to conditions such as extreme heat or pH will lead to loss of protein function. The drastic change in the three-dimensional shape is called denaturation.

What is Denaturation?

By applying some external stress or compound, such as a strong acid or base, a concentrated inorganic salt, an organic solvent, agitation and radiation or heat, proteins or nucleic acids lose the quaternary structure, tertiary structure, and secondary structure that are present in their native state. Denatured proteins affect cellular function and may even cause cell death in living cells. Cell death also leads to protein denaturation.

Denatured proteins can display a wide range of traits, including structural change, loss of solubility, and aggregation because hydrophobic groups are exposed. It is known as coagulation when solubility is lost. Denatured proteins lose their three-dimensional structure and are unable to function.

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