In 1944, oswald avery, colin macleod, and maclyn mccarty offered the first compelling experimental evidence that genes are made of deoxyribonucleic acid (dna). they showed that: The genetic material required to change a nonvirulent strain of bacteria into a virulent one was contained in DNA isolated from a virulent strain of bacteria.
- Oswald Avery's team demonstrated that DNA was the "transforming principle" in a remarkably straightforward experiment.
- DNA was able to change another strain of bacteria when it was isolated from one strain and impart traits to the other strain. Hereditary information was carried by DNA.
- From the heat-killed S strain bacteria, Avery and his team isolated and purified proteins, DNA, RNA, and other macromolecules.
- They found that DNA, which is the genetic component, is the only factor in the transformation of the R type bacterium.
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