Reactive astrocyte responses with increased number (variables), length and complexity of cellular processes.
In the central nervous system, astrogliosis promotes post-injury repair processes such as inflammation and necrosis. Axonopathy, Distal CNS and PNS - Axonal degeneration affecting distal portions of peripheral nerves and long axons of the CNS (spinal cord). PNS Distal Axonopathy - Neuropathy with degeneration of peripheral nerve endings and anterior terminal axons. Axonal rupture – Axonal injury of peripheral nerves degenerates distal to the site of injury, leaving the scaffold intact, increasing the potential for regeneration and enabling effective reinnervation. CNS blood-brain barrier – barrier to the free movement of certain substances from brain capillaries into CNS tissues. It relies on tight connections between capillary endothelial cells and selective transport systems for these cells.
The basement membrane of endothelial cells and the foot processes of astrocytes adjacent to the basement membrane may play a role in barrier function.
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