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Intradermal injection can be administered at 15-degree angle.

An intradermal injection has a mostly local and minimally systemic effect.

What is intradermal injection?

  • A material is injected superficially or shallowly into the dermis, which is situated between the epidermis and the hypodermis, during an intradermal injection, also known as ID.  
  • Due to their more complicated use, intradermal  injections are only used for specific therapies, such as tuberculosis tests and allergy tests, as they are not the preferred route of delivery for injections.
  • This is because, when used in novel closed loop insulin infusion systems, the intradermal route of administration is linked to faster systemic absorption of certain small and well soluble proteins or molecules than subcutaneous injections.
  • A tuberculin syringe calibrated in tenths and hundredths of a millilitre and a 1/4 to 1/2 in., 26 or 27 gauge needle are required for ID injections.
  • An intradermal injection typically contains less than 0.5 ml. An intradermal injection is administered at an angle of 5 to 15 degrees. An under-the-skin bleb (small blister) should form when the ID injection is finished.
  • The procedures for administering an intradermal injection are listed in Checklist 56.

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