Option A: Assembly of new nucleosomes is carried out by complexes abbreviated CAF.
CAF stands for Chromatin Assembly Factor. It forms the protein complex that moderates the assembly. It is essential to keep the synthesized DNA in a stable form.
Eukaryotic DNA is packed with proteins in the form of chromatin fibers. This chromatin structure packed with proteins is re-established during each cell cycle. DNA comprises histones, the proteins that provide structure to the nucleosome. The CAF introduces these histones onto newly synthesized DNA.
One of the two subunits of CAF-1 in humans is known as p150. It targets the CAF1 to the replication fork of DNA through protein-protein interactions with the help of Proliferating Cell Nuclear Antigen (PCNA).
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