Respuesta :
Glutamine amino acid can be precursor in de novo synthesis of both purines and pyrimidines.
- The initial reaction catalyzed by CP synthetase (CPS) is the formation of CP by combination of carbonate, ATP and an amino group from glutamine.
What amino acid is required for both purine and pyrimidine synthesis?
- Purine and pyrimidine synthesis processes are comparable and distinct from one another.
- The following are some similarities: An amino acid is included as the "core" of the purine and pyrimidine bases to be formed, and both bases require glutamine amide for their production.
Which amino acids are involved in de novo synthesis of purine?
Ribose-5-phosphate from the PPP, glycine and format from the serine/glycine synthesis route, glutamine, and aspartate from the TCA cycle are all necessary for the ten-step process of purine synthesis.
What is de novo synthesis of purine and pyrimidine?
Using 5-phosphoribosyl-1-pyrophosphate (PRPP), the de novo pathway enzymes build purine and pyrimidine nucleotides from “scratch” using simple molecules such as CO2, amino acids and tetrahydrofolate.
Learn more about pyrimidine synthesis
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