Roughly 15 times more ATPs can be produced via the complete aerobic oxidation of glucose compared to that produced by glycolysis alone.
One glucose molecule undergoes complete aerobic oxidation, yielding 38 molecules of ATP in its place. As a result, 38 molecules of water are produced, as one water molecule is split off during the creation of the phosphodiester link between ADP and inorganic phosphate.
Whereas glycolysis occurs at the first stage of cellular respiration. Oxygen is not necessary. One glucose molecule is diverged into two pyruvate molecules during glycolysis, requiring two ATP molecules while generating four ATP molecules and two NADH molecules.
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