Respuesta :
Neuronal cell growth and differentiation are influenced by valproate (VPA). However, little is known about the subsequent steps, such changes in gene transcription, that are connected to the decision of cell destiny.
By inducing proneural factors and H4 acetylation, valproic acid enhances neuronal development.
- The expression of genes related to the cell cycle and neuronal differentiation was examined to see if VPA has a teaching role in the decision of cell destiny during hippocampal neurogenesis.
- Treatment with VPA during the progenitor phases led to a significant reduction in cell division and promotion of neuronal differentiation, as well as an increase in the expression of proneural transcription factors and the number of neuronal cells.
- In response to histone deacetylase inhibitors, there is a change towards neuronal destiny as evidenced by the increased expression of Ngn1, Math1, and p15 (HDACi).
- Acetylated histone H4 (Ac-H4) was linked to the Ngn1, Math1, and p15 promoters in cultured hippocampus neural progenitor cells, according to chromatin immuno precipitation (ChIP) research.
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