Nitrogen-centered radicals (NCRs) are a versatile class of highly reactive species that have a longer history than the classical carbon-based radicals in synthetic chemistry.
The direct formation of C–N bonds onto arenes provides a simple route to synthesize a variety of important products.
Now, formation of a highly polarized, aminium radical cation enables direct C–H amination, allowing the coupling of an exceptionally broad range of alkyl amines and arenes.
Hydroamination is a reaction that involves the addition of a hydrogen and an amino group across an unsaturated C-C bond, such as that in alkenes or in alkynes.
It is a form of hydrofunctionalization with the functional group being an amine or amino derivative.
Hydroamination is most often performed catalytically.
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