Respuesta :
Peptides called protein transduction domains (PTDs) enable the internalization of cargo macromolecules (including plasmid DNA, proteins, liposomes, and nanoparticles).
What is importance of valency in enhancing the import and cell routing potential?
- The effectiveness of PTDs to encourage cellular absorption in the case of polycationic peptides is directly correlated with their molecular mass or polyvalent presentation.
- Similar to this, the number of nuclear localization signals (NLS) a cargo has increases the efficiency of routing to the nucleus.
- The identification of the PTD sequence and the cell type that is being targeted, however, both affect the quantitative improvement.
- Thus, PTD and NLS sequence selection and multivalent presentation are crucial factors in the design of macromolecules designed for precise intracellular localization.
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