Fatty acid synthesis occurs in the cytosol, while fatty acid breakdown occurs in the mitochondria.
- In biochemistry and metabolism, the cytoplasm and endoplasmic reticulum of the cell are where fatty acids are synthesized.
- In prokaryotes and eukaryotes, the cytosol is where fatty acid molecules are broken down to produce acetyl-CoA, which enters the citric acid cycle, as well as NADH and FADH2.
- The process of turning fatty acids into acetyl-CoA is known as fatty acid oxidation, and it mostly takes place in mitochondria.
- Inside the mitochondrial matrix, -oxidation breaks down fatty acids.
- One palmitate molecule, a fatty acid with 16 carbons, completely oxidizes to produce 129 ATP molecules.
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