In a Gunn rat model of hereditary hyperbilirubinemia with severe cerebellar hypoplasia, brain DNA synthesis throughout development was examined.
What does the study indicates?
- In the cerebellum of homozygous Gunn rats with cerebellar hypoplasia, the rates of protein synthesis and degradation, as well as the endogenous leucine content on days 13 and 30, were analyzed and compared with those of heterozygotes.
- On day 30, the rate of protein synthesis was much lower based on milligrams of protein, and between days 13 and 18, the rate of protein breakdown was around ten times faster.
- On day 13, leucine concentration was also almost 1.7 times higher.
- According to the current findings, the higher rate of protein degradation on day 13 and the lower rate of protein synthesis on day 30 are to blame for the reduced protein content previously seen in the cerebellum of homozygous Gunn rats.
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