The objective of this work was to create a pharmacokinetic-pharmacodynamic model to quantitatively predict the distribution of tamoxifen and endoxifen as well as to identify the anti-tumor effect patterns of these drugs.
A mass of tissue that develops abnormally when cells do not die on schedule or expand and divide more often than they should. Cancer-free tumours might be benign or malignant (cancer). Although benign tumours can become enormous, they do not penetrate or spread to surrounding tissues or to other areas of the body.
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