The biochemical process of adding a phosphate group from an inorganic phosphate (phosphate+hydrogen) to an acceptor is catalyzed by phosphorylases.
No. EC, No. CAS A glucan such as glycogen, starch, or maltodextrin is converted into glucose-1-phosphate by the action of allosteric enzymes. Glycogen phosphorylase is activated and glycogen synthase is inhibited when there is a high demand for ATP (low [ATP], low [G6P], and high [AMP]). As a result, flow via this pathway favours glycogen breakdown
Glycogen phosphorylase b is converted to the active form, glycogen phosphorylase a, by the action of PKA, which phosphorylates
phosphorylase kinase, which in turn phosphorylates Ser14 in glycogen phosphorylase b. In the liver, glucagon also stimulates a separate GPCR, which sets off a distinct cascade and stimulates phospholipase C (PLC).
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