Respuesta :
Early goal-directed therapy (EGDT), in which intravenous fluids, vasopressors, inotropes, and blood transfusions were adjusted to reach central hemodynamic targets over the course of a 6-hour protocol, significantly reduced mortality compared to standard care in a single-center study of patients who presented to the emergency department with severe sepsis and septic shock more than ten years ago. In order to determine whether these results were applicable to other situations and whether the protocol's requirements were met in its entirety, we ran a trial.
Does protocol-based resuscitation lead to better results for septic shock patients?
Early septic shock protocol-based care: a randomized trial In a multicenter trial conducted in the tertiary care setting, protocol-based resuscitation of patients in whom septic shock was diagnosed in the emergency department did not improve outcomes.
How is septic shock handled in emergency rooms in the United States?
Methods: For 6 hours of resuscitation, we randomly assigned patients with septic shock to one of three groups in 31 emergency rooms across the United States: protocol-based EGDT; protocol-based standard therapy, which did not call for the insertion of a central venous catheter; the administration of inotropes; or usual care.
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