Thickening of gill epithelia in rainbow trout, caused by chloride cell proliferation, could lead to an impairment of oxygen uptake under moderate to severe hypoxia (Thomas et al 1988; Bindon et al., 1994; Greco et al., 1995).
The number of alveolar macrophages (AMs) can rise in interstitial lung disease. Precursor cells from the peripheral circulation may have been drawn in, and/or there may have been local lung growth, to create this.
Additionally, a strong association between the quantities of lymphocytes and proliferative cells in sarcoidosis and fibrosis was discovered in bronchoalveolar lavage (BAL). Eosinophil counts and proliferating cell counts were positively associated in fibrosis.
With a substantial association between these two indices, there was a considerable increase in proliferating AMs in all patient groups when compared to healthy controls (4.2 versus 1.4% Feulgen, and 2.1 against 0.5% Ki67).
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