Respuesta :
What are the effects of Formalin fixation on MRI values?
- T1 and T2-relaxation times significantly decreased, and MWF estimates significantly increased with progressive fixation up to (and likely beyond) the time of our final measurements, 1,032 h.
- Despite neither of the diffusion measures (FA nor MD) showing significant changes as a function of formalin fixation time.
- These findings imply that in order to prevent formalin-induced changes relative to in vivo values, T1-relaxation, T2-relaxation, and MWF estimates must be performed quite early in the fixation process.
- Additionally, different ex vivo scans within an experiment must be acquired at predictable (though still early) fixation intervals in order to prevent fixative-related differences between samples.
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