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What is Passive and defensive behavior in paraventricular nucleus?
- For survival, it's crucial to choose the right passive and active defensive responses when faced with danger.
- According to earlier research, active defensive reactions predominantly depend on the nucleus accumbens, whereas passive ones depend on the central nucleus of the amygdala (CeA) (NAc).
- It is still unknown what mechanisms enable flexible switching between these two different sorts of reactions.
- In mice that the paraventricular thalamus (PVT), in conjunction with the CeA and the NAc, controls the choice of defensive actions.
- While the PVT-NAc pathway is blocked during freezing and instead communicates active avoidance events, the PVT-CeA pathway drives conditioned freezing responses.
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