The required result Limited nucleotide changes in the Rev response element (RRE) during HIV-1 infection is given below.
The HIV-1 Rev response element (RRE) is a cis-acting RNA element characterized by multiple stem loops. Binding and multimerization of the HIV Rev protein on the RRE promote the nucleocytoplasmic export of incompletely spliced mRNAs, an essential step in HIV replication.
what is Rev multimerization?
Rev is a nucleocytoplasmic transport protein that directly binds to its cis-acting Rev-responsive element RNA. Rev function depends on its ability to multimerize. The in vivo dynamics and the subcellular dependence of this process are still largely unexplored.
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